Benzene, 1-fluoro-2-(2-isocyanatoethyl)-

Benzene, 1-fluoro-2-(2-isocyanatoethyl)- - Names and Identifiers

Name	1-fluoro-2-(2-isocyanatoethyl)benzene
Synonyms	2-FLUOROPHENETHYL ISOCYANATE 97 1-fluoro-2-(2-isocyanatoethyl)benzene Benzene, 1-fluoro-2-(2-isocyanatoethyl)- Benzene, 1-fluoro-2-(2-isocyanatoethyl)- (9CI)
CAS	480439-39-2
InChI	InChI=1/C9H8FNO/c10-9-4-2-1-3-8(9)5-6-11-7-12/h1-4H,5-6H2

Benzene, 1-fluoro-2-(2-isocyanatoethyl)- - Physico-chemical Properties

Molecular Formula	C9H8FNO
Molar Mass	165.16
Density	1.152g/mLat 25°C(lit.)
Boling Point	212-213°C(lit.)
Flash Point	>230°F
Vapor Presure	0.0676mmHg at 25°C
Storage Condition	2-8℃
Refractive Index	n20/D 1.5030(lit.)

Benzene, 1-fluoro-2-(2-isocyanatoethyl)- - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R42 - May cause sensitization by inhalation
Safety Description	S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

Benzene, 1-fluoro-2-(2-isocyanatoethyl)- - Introduction

1-fluoro-2-(2-isocyyanatoethyl) benzene is an organic compound whose chemical formula is C9H8FNO. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 1-fluoro-2-(2-isocyyanatoethyl) benzene is a colorless liquid.
-Solubility: Soluble in organic solvents such as ether and alcohol, insoluble in water.
-Melting point: approximately -20°C.
-Boiling point: about 190°C.

Use:
1-fluoro-2-(2-isocyyanatoethyl) benzene is commonly used in organic synthesis as an important intermediate. It can be used to synthesize other compounds, such as drugs, dyes and polymer materials.

Preparation Method:
The preparation of 1-fluoro-2-(2-isocyyanatoethyl) benzene can be achieved by the following steps:
1. 2-fluorophenyl ethanol and isocyanate are reacted in an organic solvent.
2. Add a basic catalyst, such as trimethylamine.
3. After the reaction, the organic phase was separated, washed with an anhydrous salt solution, and then purified by distillation to obtain 1-fluoro-2-(2-isocyanatoethyl)benzene.

Safety Information:
The use and storage of 1-fluoro-2-(2-isocyyanatoethyl) benzene requires the following safety precautions:
-This compound may be irritating to skin and eyes, so direct contact with skin and eyes should be avoided. In case of accidental contact, flush with plenty of water and seek medical attention in time.
-When operating, should be equipped with suitable protective equipment, such as protective glasses and gloves, to ensure that the operation is carried out under good ventilation conditions.

Last Update：2024-04-09 20:44:15